Effect of low-dose triptorelin on pituitary down-regulation for patients undergoing in vitro fertilization and embryo transfer.
- Author:
Wen-Jie ZHU
1
;
Xue-Mei LI
;
Xiu-Ming CHEN
;
Li ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Down-Regulation; Embryo Transfer; Estradiol; blood; Female; Fertilization in Vitro; Humans; Injections, Subcutaneous; Luteinizing Hormone; blood; Luteolytic Agents; administration & dosage; Pituitary Gland; drug effects; physiology; Triptorelin Pamoate; administration & dosage
- From:National Journal of Andrology 2003;9(5):367-369
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of low-dose triptorelin in later luteal phase on pituitary down-regulation for patients undergoing IVF-ET.
METHODSOne hundred and twenty patients were randomly divided into 2 groups(A and B). In group A, the patients were treated with triptorelin of 0.1 mg subcutaneously daily started on day 21 of menstrual cycle for 7 days. In group B, the patients were treated with long protocol of Buserelin intranasal spray. Comparisons were made between the groups in serum concentrations of FSH, LH, E2, T, PRL and P on the third day (D3) of superovulation cycle and on the day of hCG administration, highly purified follicle-stimulating hormone (HP) dosages, and so on.
RESULTSIn group A, mean serum LH level on D3 and the day of hCG was (1.55 +/- 0.99) U/L and (2.70 +/- 1.45) U/L, E2 was (85.66 +/- 13.13) pmol/L and (5,451.31 +/- 1,900.61) pmol/L, respectively, significantly lower than those of group B (P < 0.001; P < 0.01; P < 0.05; P < 0.001). Mean HP(75 IU/Amp) dosage per treatment cycle in group A was 28.20 +/- 11.03 ampoules, significantly higher than 22.30 +/- 6.40 ampoules in group B(P < 0.001).
CONCLUSIONSLow-dose triptorelin in later luteal phase is effective for down-regulation of pituitary and produces more suppression on endogenous LH in pituitary than Buserelin long protocol.
