Allotransplantation of spermatogonial stem cells in KM mice.
- Author:
Ci ZHANG
1
;
Ling-Long WANG
;
Chao SONG
;
Hua-Min JIN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Male; Mice; Models, Animal; Spermatogonia; cytology; transplantation; Stem Cell Transplantation; Testis; cytology; Transplantation, Homologous
- From: National Journal of Andrology 2003;9(6):417-420
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the feasibility of spermatogonial stem cell allotransplantation.
METHODSThe spermatogonial stem cell allotransplantation was performed, without the use of immune inhibitor, in KM mice of similar gene types, and the spermatogenesis in recipients' testes was evaluated. The right testes were pierced for transplantation while the left ones were taken as control.
RESULTSAllotransplant germ cells in KM mice can recover normal function of spermatogenesis in the transplanted testis without any immune suppression.
CONCLUSIONAllospermatogonial stem cells can be transplanted successfully among KM mice.
