Tumor infiltrating dendritic cells and Mucin1 gene expression in benign prostatic hyperplasia and prostate cancer.
- Author:
Song-Tao XIANG
1
;
Si-Wei ZHOU
;
Wei GUAN
;
Qin-Zhang WANG
;
Bao ZHANG
;
Ji-Hong LIU
;
Zhang-Qun YE
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, Neoplasm; biosynthesis; Dendritic Cells; immunology; Humans; Immunohistochemistry; Lymphocytes, Tumor-Infiltrating; immunology; Male; Mucin-1; Mucins; biosynthesis; Prostatic Hyperplasia; immunology; metabolism; pathology; Prostatic Neoplasms; immunology; metabolism; pathology
- From: National Journal of Andrology 2003;9(7):497-500
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of Mucin1 gene and tumor infiltrating dendritic cells(TIDC) in the tissues of benign prostatic hyperplasia (BPH) and prostate cancer.
METHODSMucin1 and TIDC were detected in 20 specimens of BPH and 30 specimens of prostate cancer by immunohistochemistry SP method.
RESULTSMUC1 expressed in both prostate cancer and BPH. The staining patterns were significantly associated with tumor pathological grade (P < 0.001). The number of TIDC was negatively correlated with tumor pathological grade, the higher the grade, the smaller the number of TIDC (P < 0.001).
CONCLUSIONSThe expression pattern of MUC1 and the number of TIDC could be considered as useful markers to evaluate the malignant degree and prognosis of prostate cancer. The decrease of TIDC plays an important role in tumor immune evasion and immune tolerance. Highly expressed MUC1 could lead to the failure of hormonal treatment for prostate cancer, and contribute much to tumor infiltration and metastasis.
