NF-kappa B and prostatic adenocarcinoma.
- Author:
Song-Tao XIANG
1
;
Hui GUO
;
Si-Wei ZHOU
Author Information
1. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
pathology;
therapy;
Cell Line, Tumor;
Gene Expression Regulation, Neoplastic;
Genetic Therapy;
Humans;
Male;
NF-kappa B;
physiology;
Neoplasm Invasiveness;
physiopathology;
Neoplasm Metastasis;
physiopathology;
Prostatic Neoplasms;
pathology;
therapy
- From:
National Journal of Andrology
2003;9(7):536-542
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor of kappa B (NF-kappa B) is a multipolar nuclear transcription factor, and adjusts many gene expressions concerned with immunization, apoptosis, inflammation, neoplasia and metastasis. Recently, NF-kappa B has become a kind of hot spot in the studies of neoplasia, infiltration, metastasis and drug resistance. NF-kappa B can serve as an ideal target molecular approach to the promising gene therapy. This article reviews recent advances in studies on the structure and function of NF-kappa B, and the relationship between NF-kappa B and prostatic adenocarcinoma infiltration, metastasis and tactics of gene therapy.
