Effects of daidzein on sperm quality, testis gain and testosterone in mice.
- Author:
Zhao-Yu HAN
1
;
Gen-Lin WANG
;
Wen CHEN
;
Li-Jun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Survival; drug effects; Dose-Response Relationship, Drug; Isoflavones; pharmacology; Male; Mice; Mice, Inbred Strains; Organ Size; drug effects; Phytoestrogens; pharmacology; Spermatozoa; cytology; drug effects; Testis; drug effects; Testosterone; blood
- From: National Journal of Andrology 2003;9(8):566-568
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of daidzein on sperm quality of male mice.
METHODSThree different doses of daidzein were supplemented to pubertal male mice for 21 days(5 mg/kg, 100 mg/kg, 1,000 mg/kg ration). The viability of sperm was determined by eosin-Y, the acrosome was observed by Wright-Giemsa staining, and the testosterone was measured by radioimmunoassay.
RESULTSDaidzein at the dose of 5 mg/kg ration significantly increased serum testosterone levels (P < 0.01), prompted testis gain (P < 0.05), and improved spermatozoa quality. Daidzein at dose of 1,000 mg/kg ration could inhibit the secretion of serum testosterone (P < 0.01), without significant variation in spermatozoa quality. Daidzein at dose of 100 mg/kg ration did not significantly affect sperm quality and other index.
CONCLUSIONSDaidzein can affect sperm quality and in dosage-dependant ways.
