Treatment of Epidermal Growth Factor Receptor Inhibitors Associated Adverse Skin Reactions by Zhiyang Pingfu Liquid: a Clinical Study.
- Author:
Hong-yan WANG
;
Chao ZOU
;
Hui-juan CUI
;
Yan-ping BAI
;
Yuan LI
;
Huang-ying TAN
;
Wei WANG
;
Hai JU
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; adverse effects; Biomedical Research; Drugs, Chinese Herbal; administration & dosage; therapeutic use; Exanthema; chemically induced; Humans; Neoplasms; drug therapy; Pruritus; Receptor, Epidermal Growth Factor; antagonists & inhibitors; Skin; drug effects; Skin Diseases; drug therapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2015;35(7):820-822
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the curative effect of Zhiyang Pingfu Liquid (ZPL) in treating epidermal growth factor receptor inhibitors (EGFRIs) associated adverse reactions of the skin.
METHODSAll 54 patients with pathologically confirmed malignant tumor had EGFRIs induced adverse reactions of the skin to various degrees. ZPL was externally applied for them all, once or twice per day, 14 days consisting of one therapeutic course. Changes of adverse skin reactions, time for symptoms relief, adverse skin reaction types suitable for ZPL were observed before and after treatment.
RESULTSEGFRIs associated skin adverse reactions were improved to various degrees after they used ZPL. The shortest symptoms relief time was 1 day while the longest was 12 days, with an average of 6.93 days and the median time 7 days. Compared with before treatment, itching, rash/scaling, acne/acneform eruptions were obviously improved (P < 0.05).
CONCLUSIONZPL could alleviate EGFRls associated adverse skin reactions, especially showed better effect on itching, rash/scaling, acne/acneform eruptions.