Clinical Application of Immune-related Response Criteria in Evaluating Chinese Medical Treatme for Advanced Non-small Cell Lung Cancer.
- Author:
Hai-wei JIANG
;
Qing HU
;
Dan-feng HE
;
Chang GAO
;
Yan-hong YAN
;
Lin-tong GE
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; Carcinoma, Non-Small-Cell Lung; drug therapy; immunology; Drugs, Chinese Herbal; therapeutic use; Humans; Lung Neoplasms; drug therapy; immunology; Medicine, Chinese Traditional; standards; Treatment Outcome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2015;35(9):1074-1077
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the applicability of immune-related response criteria (irRC) in treating non-small cell lung cancer (NSCLC) by Chinese medicine (CM).
METHODSTotally 97 stage III a-IV NSCLC patients were predominantly treated with comprehensive CM. Curative effects were evaluated by three methods such as Response Evaluation Criteria in Solid Tumors (RECIST), Oncologic Curative Effect Evaluation Criteria of Chinese Medicine in Solid Tumor (draft, abbreviated as CM criteria), and irRC. The correspondency and consistency between irRC, RECIST and CM criteria were analyzed and compared. The objectivity of irRC in evaluating curative effect of Chinese medical treatment for NSCLC was assessed.
RESULTSThe correspondency rate of irRC to RECIST was 59. 79% with Kappa value of 0. 379 (U test, P <0. 01). The two criteria had certain correspondence, but with an unsatisfactory consistency. The correspondency rate of irRC to CM criteria rate was 83. 51% with Kappa value of 0.751 (U test, P <0. 01). The two criteria had good correspondence and consistency.
CONCLUSIONSCM criteria had good consistency with CM criteria in evaluating curative effect for Chinese medical treatment of advanced NSCLC. Its results could objectively reflect features and advantages of CM for treating advanced NSCLC.