OBJECTIVETo observe bone ingrowth of artificial femur which three dimensions (3-D) porous Ti combined bone morphogenetic proteins (BMPs) integrating on the prostheses surface in dogs.

METHODSThe prostheses integrated 3-D porous Ti on the surface, which combined BMPs directly or through FG, were implanted canine. And fluorescent labeling was done at 2, 5 weeks after that, and then the prostheses with femurs were taken out in 3, 6 weeks after operation. These specimens were treated, then observed through microscopy.

RESULTSAt 3 weeks, bone growing 1/2 of full thickness in 3-D porous Ti, but bone growing full thickness in 3-D porous Ti at 6 weeks. Bone formation was obviously higher at 6 weeks than at 3 weeks.

CONCLUSIONThe prostheses modified 3-D porous Ti can accelerate osteogenesis and improve bone formation so that mechanical interlock and integration can be come true.