Sub-endplate microcirculation disturbance directly contributes to intervertebral disc degeneration.
- Author:
Zhao-Min ZHENG
1
;
You LÜ
;
Hui CHEN
;
Hui LIU
;
Kui-Bo ZHANG
;
Fo-Bao LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Female; Intervertebral Disc; blood supply; metabolism; pathology; Male; Microcirculation; Rabbits; Random Allocation; Thrombosis; complications; metabolism; pathology
- From: Chinese Journal of Surgery 2008;46(3):213-216
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo build sub-endplate microcirculation disturbance animal model and to investigate the potential pathogenesis of intervertebral disc degeneration (IVDD).
METHODSTwenty four New Zealand white rabbits were divided into treatment group (Group A) and control group (Group B). In Group A, animals received endotoxin and corticosteroid application to build sub-endplate microcirculation disturbance animal model, validated by microthrombus staining. In Group B, animals were given no drug, but standard feeding. After 3 month, the extent of IVDD was evaluated by the water content, biochemistry analysis, and morphology.
RESULTSSub-endplate microthrombus staining confirmed the exist of microcirculation disturbance. The water content and biochemistry components content of disc in Group A were lower than those of disc in Group B, and IVDD was observed in morphology.
CONCLUSIONSub-endplate microcirculation disturbance can directly contribute to IVDD, the nutrients diffusion barrier is the potential pathogenesis of IVDD.
