Comparison of bioavailability of two kinds of solid dispersion from 10-hydroxycamptothecin in SD rats in vivo.
- Author:
Xian-Chuang WU
1
;
Hai-Jun HAO
2
;
Yu-Xin LIU
1
;
Xiao-Yong SONG
1
;
Yong-Zhou ZHANG
1
;
Hong-Qin ZHANG
3
Author Information
- Publication Type:Journal Article
- Keywords: 10-hydroxycamptothecin; bioavailability; solid dispersion
- From: China Journal of Chinese Materia Medica 2016;41(6):1130-1134
- CountryChina
- Language:Chinese
- Abstract: To improve the bioavailability of 10-hydroxycamptothecin, 10-hydroxycamptothecin solid dispersion(HCPT-SD) and 10-hydroxycamptothecin-phospholipid complex-solid dispersion(HCPT-PC-SD) were prepared, and their solubility and dissolution rate were evaluated in this study. SD rates were administered intragastrically with HCPT-SD or HCPT-PC-SD respectively, then their blood samples were collected at different time intervals. The concentration of HCPT in blood was detected by HPLC method with camptothecin as internal standard, and then its pharmacokinetic parameters were calculated and obtained. The results showed that the Cmax, AUC0-t and AUC0-∞ of both kinds of solid dispersion of HCPT were significantly increased than those of crude drug. The AUC0-t of HCPT-SD was increased by 176.87%, and AUC0-t of HCPT-PC-SD was increased by 254.31% as compared with crude drug. Therefore, the two kinds of solid dispersion of HCPT could significantly enhance the bioavailability of HCPT in SD rates, and the effect of HCPT-PC-SD was more obvious.
