Study on mechanism for anti-hypertension efficacy of Eucommiae Cortex through assistant analysis systems for acting mechanisms of traditional Chinese medicine.
- Author:
Xiao-tong YE
;
Bai-xia ZHANG
;
Hui-hui WANG
;
Shuai-bing HE
;
Xiao-hua ZHANG
;
Yun WANG
- Publication Type:Journal Article
- MeSH:
Animals;
Antihypertensive Agents;
administration & dosage;
chemistry;
Databases, Factual;
Drugs, Chinese Herbal;
administration & dosage;
chemistry;
Essential Hypertension;
Eucommiaceae;
chemistry;
Gene Regulatory Networks;
drug effects;
Humans;
Hypertension;
drug therapy;
genetics;
metabolism;
Signal Transduction;
drug effects
- From:
China Journal of Chinese Materia Medica
2015;40(19):3718-3722
- CountryChina
- Language:Chinese
-
Abstract:
Elucidate the mechanism of Eucommiae Cortex in treatment of hypertension, to provide the basis for further research and development of Eucommiae Cortex. Our study using the entity grammar systems inference rules to analyse the interactions of chemical constituents of Eucommiae Cortex and disease target proteins at the molecular level, and got a biological network of Eucommiae Cortex anti-hypertension which inciude 602 nodes and 2 354 edges. We got 3 treatment of hypertension pathways of Eucommiae Cortex by analyzing biological network, that is, by inhibition of vascular remodeling to improve the deterioration of hypertension, reduce activity of polymorphism genetic genes related to essential hypertension, inhibition of carbonic anhydrase 1 to maintain the osmotic pressure, Eucommiae Cortex play the role of anti-hypertension.
