Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica.
- Author:
Yu-guang WANG
;
Xian-xie ZHANG
;
Han LI
;
Bei-bei LU
;
Jian-ming ZHOU
;
Hao-sheng LIU
;
Dong-hua HU
;
Tao ZHOU
;
Ya-xin ZHANG
;
Zeng-chun MA
;
Qian-de LIANG
;
Xiang-lin TANG
;
Cheng-rong XIAO
;
Hong-ling TAN
;
Yue GAO
- Publication Type:Journal Article
- MeSH: Animals; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; pharmacology; Gene Expression; drug effects; Humans; Receptors, Steroid; antagonists & inhibitors; genetics; metabolism
- From: China Journal of Chinese Materia Medica 2015;40(17):3444-3449
- CountryChina
- Language:Chinese
- Abstract: Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.