ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus.
10.4093/kdj.2010.34.5.320
- Author:
Dae Joon JEONG
1
;
Dong Gyu LEE
;
Hee Jung KIM
;
Eun Hee CHO
;
Sang Wook KIM
Author Information
1. Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea. exoplanet@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Coronary artery calcification;
Diabetes mellitus, type 2;
Ectonucleotide pyrophosphatase phosphodiesterase 1
- MeSH:
Aged;
Calcium;
Cardiovascular Diseases;
Coronary Vessels;
Diabetes Mellitus, Type 2;
Diphosphates;
Genotype;
Homozygote;
Humans;
Lifting;
Phosphoric Diester Hydrolases;
Prevalence;
Pyrophosphatases
- From:Korean Diabetes Journal
2010;34(5):320-326
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients. METHODS: The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified. RESULTS: The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959). CONCLUSIONS: The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.
