Development of Fuzi precision decoction pieces (PDP) (I): Specification and quality uniformity.
- Author:
Ding-kun ZHANG
;
Xue HAN
;
Yong-feng ZHOU
;
Peng TAN
;
Ming YANG
;
Cheng PENG
;
Jia-bo WANG
;
Xiao-he XIAO
- Publication Type:Journal Article
- MeSH:
Aconitum;
chemistry;
Chemistry, Pharmaceutical;
methods;
Chromatography, High Pressure Liquid;
Particle Size;
Plant Extracts;
chemistry;
pharmacology;
Quality Control
- From:
China Journal of Chinese Materia Medica
2015;40(17):3488-3495
- CountryChina
- Language:Chinese
-
Abstract:
The specification of decoction pieces and quality uniformity are the important factors to influence the efficacy of clinical medicine. Considering the deficiency of diversity, poor quality uniformity and confusion of decoction pieces specifications, we first propose a new idea of precision decoction pieces (PDP) based on clinical demands and fresh-processed technology. In order to explain the idea, a study case of aconite SUP is provided, including the optimized specification design, processing technology, extraction effects, quality uniformity, and toxic and efficacy variation and so on. The results showed that preparing 5 mm PDP by fresh-cutting is rather simple and practicable, with high efficiency and large yield; then, this technology could significantly decrease the ingredients loss and increase the efficacy components; moreover, it was helpful for achieving the quality uniformity and best extraction effects. This work revealed the quality superiority of PDP, and provided a good strategy and example for the standard of decoction pieces specification and modernization of processing technology.
