Studies on chemical constituents of aqueous extract of Lonicera japonica flower buds.
- Author:
Yang YU
;
Wei-xia SONG
;
Qing-lan GUO
;
Sheng LIN
;
Su-juan WANG
;
Yong-chun YANG
;
Jian-gong SHI
- Publication Type:Journal Article
- MeSH:
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
Flowers;
chemistry;
Lonicera;
chemistry;
Mass Spectrometry;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2015;40(17):3496-3504
- CountryChina
- Language:Chinese
-
Abstract:
From an aqueous extract of Lonicera japonica flower buds, sixteen compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, MCI gel, silica gel, and sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by spectroscopic data analysis as 6'-O-acetylvogeloside (1), 6'-O-acetylsecoxyloganin (2), dichlorogelignate (3), guanosinyl-(3' --> 5')-adenosine monophosphate(GpA,4) , 5'-O-methyladenosine (5), 2'-O-methyladenosine (6), adenosine (7), syringin (8), methyl 4-O-β-D-glucopyranosyl caffeate (9), (-)-dihydrophaseic acid 4'-O-β-D-glucopyranoside (10), ketologanin (11), 7α-morroniside (12), 7β-morroniside (13), kingiside (14), cryptochlorogenic acid methyl ester (15), and 6-hydroxymethyl-3-pyridinol (16). All the compounds were obtained from this plant for the first time, compounds 1 and 2 are new compounds, 3 and 5 are new natural products, and 4 is the first example of dinucleoside monophosphate isolated from a plant extract.
