Preparation and stability of β-carotene loaded using mesoporous silica nanoparticles as carriers system.
- Author:
Jing LIU
;
Zhi-hui REN
;
Hai-yuan WANG
;
Xing-hua JIN
- Publication Type:Journal Article
- MeSH:
Drug Carriers;
chemistry;
Drug Delivery Systems;
Drug Stability;
Nanoparticles;
chemistry;
Silicon Dioxide;
chemistry;
beta Carotene;
chemistry;
pharmacology
- From:
China Journal of Chinese Materia Medica
2015;40(18):3579-3584
- CountryChina
- Language:Chinese
-
Abstract:
1,3,5-Trimethylbenzene (1,3,5-TMB) was used as the pore-enlarging modifier to expand the pore size of MCM-41 (mobil company of matter) mesoporous silica nanoparticles. The solvent impregnation method was adopted to assemble non-water-soluble β-carotene into the pore channel of MCM-41. The MCM-41 and drug assemblies were characterized by TEM, FT-IR, elemental analysis and N2 adsorption-desorption. The results showed that MCM-41 has good sphericity and regular pore structure. The research also investigated the optimal loading time, the drug loading and the vitro stability of the β-carotene. As a drug carrier, the modified MCM-41 showing a shorter drug loading time, the drug loading as high as 85.58% and the stability of β-carotene in drug assemblies has improved. The study of this new formulation provides a new way for β-carotene application.
