Optimization of spraying dry technology of Biqiu ranules ethanol extract by Box-Behnken response surface method.
- Author:
Yan-jun ZHANG
;
Li-li LIU
;
Jun-hua HU
;
Yun WU
;
En-xiang CHAO
;
Wei XIAO
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
methods;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
Ethanol
- From:
China Journal of Chinese Materia Medica
2015;40(18):3585-3589
- CountryChina
- Language:Chinese
-
Abstract:
With inlet temperature, specific gravity, feeding speed as independent variables, the comprehensive evaluating indexes of content of schisandrin and arctiin as dependent variable, the experimental data were fitted to a second order polynomial equation. Based on establishing the mathematical relationship between the comprehensive evaluating indexes and respective variables, Box-Benhnken central composite test and response surface analysis method was employed to optimize the spray drying technology of Biqiu granules ethanol extract. The optimal drying parameter was as follows: the inlet temperature was 175 degrees C, the specific gravity was 1.10, feeding speed was 32 r x min(-1). Under these conditions, the comprehensive evaluating indexes of spraying dry processes was 92.68, which was close to the model prediction. The spraying dry technology of Biqiu granules ethanol extract optimized by response surface methodology was accurate and feasible, which provided theoretical experiment basis for the industrialization production.
