Studies on coumarins from fruit of Cnidium monnieri and their cytotoxic activities.
- Author:
Xu-hong DUAN
;
Yu-zhuo ZHANG
;
Pei HE
;
Zong-min MA
;
Lin PEI
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Cnidium;
chemistry;
toxicity;
Coumarins;
chemistry;
isolation & purification;
toxicity;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
toxicity;
Fruit;
chemistry;
toxicity;
Mice;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2015;40(18):3594-3597
- CountryChina
- Language:Chinese
-
Abstract:
This study is to study is to investigate the coumarins from Fruit of Cnidium monnieri and their cytotoxic activities. The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The isolated compounds were evaluated for their cytoxic activities by MTT method. Eleven compounds were isolated and identified as osthole (1), bergaptan (2), xanthotoxol (3), xanthotoxin (4), imperatorin (5), isopimpinellin (6), osthenol (7), psoralen (8), 5,7-dimethoxycoumarin (9), oxypeucedaninhydrate (10), and swietenocoumarin F (11). Compounds 7, 9-11 were isolated from the Cnidium genus for the first time. Compounds 1,5,10 and 11 showed significant cytotoxic activities against L1210 cell lines at a concentration of 1 x 10(-5) mol x L(-1) with inhibitory rates of were 70.13, 63.10, 55.77, and 75.08% respectively.
