Prediction of the GVHD after allo-HSCT by sequence similar matching method.
- Author:
Dan-Dan ZHAO
1
;
Zhou-Yang LIU
;
Yong-Bin CAO
;
Shuang JIANG
;
Wan-Ming DA
;
Xiao-Xiong WU
Author Information
1. Department of Hematology, 304th Clinical Division, Chinese PLA General Hospital, Beijing 100048 China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Child;
Female;
Graft vs Host Disease;
diagnosis;
etiology;
Hematopoietic Stem Cell Transplantation;
adverse effects;
methods;
Histocompatibility Testing;
methods;
Humans;
Male;
Middle Aged;
Transplantation, Homologous;
adverse effects;
Young Adult
- From:
Journal of Experimental Hematology
2010;18(3):740-743
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the role of sequence similar matching (SSM) method in prediction of GVHD after HLA unmatched allogeneic hematopoietic stem cell transplantation (allo-HSCT). The data from 23 patients undergoing HLA unmatched allo-HSCT were analyzed and calculated by SSM method. The results showed that the incidence of acute and severe GVHD were significantly less in the allo-HSCT cases with total SSM value less than 55. In conclusion, the SSM method can be used to predict GVHD in the HLA-unmatched allogeneic hematopoietic stem cell transplantation.
