Clonal expanded T-cell repertoire in MDS.
- Author:
Yang-Qiu LI
1
;
Xin DU
Author Information
1. Institute of Hematology, Jinan University Medical College, Guangzhou 510632, Guangdong Province, China. jnyangqiuli@163.com
- Publication Type:Journal Article
- MeSH:
Clone Cells;
Humans;
Myelodysplastic Syndromes;
immunology;
Receptors, Antigen, T-Cell;
immunology;
T-Lymphocytes;
cytology;
immunology
- From:
Journal of Experimental Hematology
2010;18(3):793-797
- CountryChina
- Language:Chinese
-
Abstract:
The myelodysplastic syndromes (MDS) comprises a heterogeneous group of clonal hematopoietic stem cell disorders, while immunological abnormalities are frequently observed in such patients. T-cell mediated suppression of hematopoietic precursors contributes to the cytopenia and is related to the initiation and development of myelodysplastic syndromes (MDS). In this review, current knowledge concerning the feature of T-cell clonal expansion in MDS based on the analysis of T-cell receptor repertoire is summarized, including following issues: autoimmunity in MDS patients associated with T-cell mediated suppression of hematopoiesis, characteristics of T-cell clonal expansion in MDS patients, change of T-cell repertoire and recent thymus output function in MDS patients, efficiency of immunosuppressive treatment associated with T-cell clonal expansion in MDS patients and significance of T-cell clonal analysis in clinical application.
