Relationship of alloreactive NK cells to prognosis of HLA-identical sibling allogeneic hematopoietic stem cell transplantation.
- Author:
Bi-Yun PENG
1
;
Xiao-Wen TANG
Author Information
1. Key Laboratory of Thrombosis and Hemostasis Subordinate to Ministry of Health, Jiangsu Institute of Hematology, Suzhou University First Hospital, Suzhou 215006, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
HLA Antigens;
immunology;
Hematopoietic Stem Cell Transplantation;
methods;
Humans;
Killer Cells, Natural;
immunology;
Prognosis;
Receptors, KIR;
immunology;
Siblings;
Transplantation, Homologous
- From:
Journal of Experimental Hematology
2010;18(3):803-808
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the interaction between HLA class I alleles and receptors of NK cells have been paid more attention in HLA-identical sibling hematopoietic stem cell transplantation (HLA-identical sibling HSCT). NK cells mediate alloreactions when the allogeneic targets do not express HLA class I alleles that block inhibitory receptors of NK cells. Alloreactive donor-derived NK cells reduce GVHD by eliminating host-type antigen-presenting cells, but favor engraftment by killing host lymphocyte cells and reduce the risk of relapse by eradicating leukemia cells. Moreover, activating receptors also influence the outcome of HLA-identical sibling HSCT. In this review, the advance of the impact of both inhibitory and activating KIR (killer cell immunoglobulin-like receptor, KIR) on the outcome of HLA-identical sibling HSCT is briefly summarized.
