Research advances on relationship between suppressor of cytokine signaling 3 and myeloproliferative neoplasms.
- Author:
Wei QIN
1
;
Jian-Fei FU
Author Information
1. Department of Hematology, Tongji Hospital of Tongji University, Shanghai 200065, China.
- Publication Type:Journal Article
- MeSH:
Cytokines;
metabolism;
Humans;
Myeloproliferative Disorders;
metabolism;
Signal Transduction;
Suppressor of Cytokine Signaling 3 Protein;
Suppressor of Cytokine Signaling Proteins;
metabolism
- From:
Journal of Experimental Hematology
2010;18(4):1101-1104
- CountryChina
- Language:Chinese
-
Abstract:
Suppressor of cytokine signaling (SOCS) is a protein family negatively regulating signal transduction pathway of a certain class of cytokines and growth factors. More than 20 members have been found in SOCS family, SOCS3 is one of them and has been studied hottest and most clearly. Recent studies demonstrated that SOCS3 abnormalities were found in patients with myeloproliferative neoplasms (MPN), suggesting that SOCS3 plays a significant role in the pathogenesis, development and metastasis in MPN. In this review, the advances of research on relationship between SOCS3 and MPN were summarized, including general profile of SOCS family; structure, function and regulation of SOCS3, relation of SOCS3 to MPN and so on.
