Relationship between body weight status in early adulthood and body weight change at middle age in adults and type 2 diabetes mellitus
10.3760/cma.j.issn.0254-6450.2016.03.009
- VernacularTitle:成年早期体重状态及至中年期体重变化与新发2型糖尿病的关系
- Author:
Long ZHOU
1
;
Liancheng ZHAO
;
Ying LI
;
Min GUO
;
Yangfeng WU
Author Information
1. 中国医学科学院北京协和医学院国家心血管病中心阜外医院社区防治部
- Keywords:
Body weight;
Obesity;
Type 2 diabetes mellitus
- From:
Chinese Journal of Epidemiology
2016;37(3):339-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between weight status in early adulthood and body weight change at middle age in adults and type 2 diabetes mellitus (T2DM).Methods The data of 14 population samples from China Multicenter Collaborative Study of Cardiovascular Epidemiology conducted in 1998 were used.Approximately 1 000 men and women in each sample were surveyed for cardiovascular disease risk factors,including body weight at age 25 years.The body mass index (BMI) at the age 25 years was calculated.The association between body weight in early adulthood and body weight change at middle age and T2DM was examined by using logistic regression model.Results The incidence of T2DM in low weight group (BMI＜ 18.5 kg/m2),normal weight group (BMI:18.5-23.9 kg/m2),overweight group (BMI:24.0-27.9 kg/m2) and obese group (BMI:≥28.0 kg/m2) at 25 years old were 2.4％(30/1 263),2.8％(266/9 562),4.0％(70/1 739) and 6.4％ (7/110),respectively (P value for trend＜0.01).The incidence of T2DM for adults with weight change ＜-7.5 kg,-7.5--2.6 kg,-2.5-2.5 kg,2.6-7.5 kg,7.6-12.5 kg and ＞ 12.5 kg at middle age were 2.5％ (18/712),1.3％(21/1 629),2.1％(48/2 330),2.3％(59/2 585),3.7％(94/2 518),and 4.6％(133/ 2 900) respectively.(P value for trend ＜0.01),Multivariate logistic regression analysis showed that overweight and obesity at age 25 years and subsequent weight gain were positively correlated with T2DM after adjusted other risk factors (all P values for trend ＜0.01).Conclusion Overweight and obesity in early adulthood and weight gain at middle age were both independently associated with the increased risk of T2DM in middle-aged men and women.
