Association between HLA-DQ gene polymorphisms and different outcomes of hepatitis B virus infection
10.3760/cma.j.issn.0254-6450.2016.03.019
- VernacularTitle:HLA-DQ基因多态性与HBV感染不同临床结局的关联研究
- Author:
Wenxuan LIU
1
;
Xiaolin ZHANG
;
Xia GAO
;
Lei YANG
;
Baoxin LI
;
Dianwu LIU
Author Information
1. 河北医科大学流行病与卫生统计学教研室
- Keywords:
Hepatitis B virus;
Human leucocyte antigen;
Single nucleotide polymorphism
- From:
Chinese Journal of Epidemiology
2016;37(3):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the association between two single-nucleotide polymorphism (HLA-DQ rs28567185 and rs9275572) and different outcomes of hepatitis B virus (HBV) infection.Methods A total of 825 HBV infection related cases were enrolled,and peripheral blood samples were collected from them for DNA extraction.The single-nucleotide polymorphism in HLA-DQ region were genotyped by using matrix-assisted laser desorption/ionization time of flight mass spectrometry.Logistic regression analysis was conducted to evaluate the association between HLA-DQ gene polymorphism and different outcomes of hepatitis B virus infection.Results Our study indicated that cases with HLA-DQ rs2856718G (524 cases) and rs9275572A (369 cases) had reduced susceptibility to HBV infection (OR=0.702,95％CI:0.558-0.856,P=0.001;OR=0.548,95％C1:0.365-0.847,P=0.005) and higher HBV natural clearance (OR=0.589,95％ CI:0.478-0.892,P=8.81 × 10-3;OR=0.673,95％CI:0.457-0.860,P=0.014).Moreover,rs9275572A was also associated with the lower risk of the development of hepatocellular carcinoma (OR=0.759,95％CI:0.538-0.914,P=0.041).Conclusion Our study suggested that HLA-DQ loci might be associated with the different outcomes of HBV infection in Chinese in Han ethnic group in northern China,rs2856718G and rs9275572A might be protective factors for HBV infection,HBV natural clearance and HBV-related disease progress.
