Detection of neutralizing antibodies and DNA of human papillomavirus 16, 18 in women aged 18-45 years in Funing, Jiangsu province.

Wenyu Liu; Feixue Wei; Jie Tang; Shangbo Yang; Yachun Gao; Ting Wang; Yunfei Jiang; Mei LI; Ying Hong; Kai Chu; Wen Chen; Yuemei HU; Fengcai Zhu

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Detection of neutralizing antibodies and DNA of human papillomavirus 16, 18 in women aged 18-45 years in Funing, Jiangsu province.

Author: Wenyu LIU ¹ ; Feixue WEI ² ; Jie TANG ¹ ; Shangbo YANG ¹ ; Yachun GAO ¹ ; Ting WANG ¹ ; Yunfei JIANG ³ ; Mei LI ³ ; Ying HONG ³ ; Kai CHU ⁴ ; Wen CHEN ⁵ ; Yuemei HU ⁴ ; Fengcai ZHU ⁴
Author Information

1. Funing County Center for Disease Control and Prevention of Jiangsu Province, Funing 224400, China.
2. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361100, China.
3. The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
4. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
5. Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Antibodies, Neutralizing; isolation & purification; Antibodies, Viral; isolation & purification; China; DNA, Viral; isolation & purification; Female; Human papillomavirus 16; immunology; Human papillomavirus 18; immunology; Humans; Middle Aged; Papillomavirus Infections; prevention & control; Papillomavirus Vaccines; Young Adult
From: Chinese Journal of Epidemiology 2016;37(3):406-409
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo understand the distributions of DNA and neutralizing antibodies of human papillomavirus (HPV)16, 18 in 18-45 year-old women.
METHODSTotally, 1494 women were enrolled through multistage random sampling in Funing, Jiangsu province. Cervical exfoliated cells were collected from them for HPV DNA testing, and serum samples were taken from them for the detection of HPV16, 18 neutralizing antibodies by using pseudovirion-based neutralization assay(PBNA).
RESULTSAmong the 1494 women, 28(1.9%) and 188(12.6%) were positive for DNA and neutralizing antibody of HPV16 respectively, and 15(1.0%) and 60(4.0%) were positive for DNA and neutralizing antibody of HPV18, respectively. There were no significant differences in the detection rates of DNA and neutralizing antibody of HPV16, 18 among different age groups. About 16.7% of the women were infected with HPV16, 18, or both.
CONCLUSIONIn Funing county of Jiangsu province, most women aged 18-45 years has no immunity to HPV16 and 18, indicating that they are appropriate targets for HPV 16/18 vaccination.