A co-twin control study on birth weight, overweight and obesity among children younger than 18 years old in China.

Qingqing Liu; Canqing YU; Wenjing Gao; Weihua Cao; Jun Lyu; Shengfeng Wang; Zengchang Pang; Liming Cong; Zhong Dong; Fan WU; Hua Wang; Xianping WU; Dezheng Wang; Binyou Wang; Liming LI

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A co-twin control study on birth weight, overweight and obesity among children younger than 18 years old in China.

VernacularTitle:中国18岁以下双生子出生体重与超重/肥胖的关联分析
Author: Qingqing LIU ¹ ; Canqing YU ¹ ; Wenjing GAO ¹ ; Weihua CAO ¹ ; Jun LYU ¹ ; Shengfeng WANG ¹ ; Zengchang PANG ² ; Liming CONG ³ ; Zhong DONG ⁴ ; Fan WU ⁵ ; Hua WANG ⁶ ; Xianping WU ⁷ ; Dezheng WANG ⁸ ; Binyou WANG ⁹ ; Liming LI ¹
Author Information

1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Qingdao Center for Disease Control and Prevention, Qingdao 266033, China.
3. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
4. Department of Chronic and Non-communicable Disease Control and Prevention, Beijing Center for Disease Control and Prevention, Beijing 100013, China.
5. Shanghai Center for Disease Control and Prevention, Shanghai 200336, China.
6. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
7. Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China.
8. Department of Chronic and Non-communicable Disease Control and Prevention, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China.
9. Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China.
Publication Type:Journal Article
MeSH: Adolescent; Birth Weight; Child; Child, Preschool; China; epidemiology; Female; Humans; Male; Obesity; ethnology; Overweight; ethnology; Registries; Risk; Twins, Dizygotic; Twins, Monozygotic
From: Chinese Journal of Epidemiology 2016;37(4):464-468
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo analyze the associations between birth weight and overweight/obesity among children.
METHODSA total of 8 267 twin pairs younger than 18 years old from the Chinese National Twin Registry were included in the study. Associations between birth weight, childhood BMI and overweight/obesity were explored by this co-twin control study.
RESULTSAfter adjusting for sex and zygosity, when birth weight had an increase of 0.5 kg per fold, the OR values for overweight and obesity were 1.87(95%CI: 1.40-2.48) for 2-6 year olds, 1.69 (95%CI: 1.16-2.46) for 6-12 year olds and 1.28 (95%CI: 0.80-2.07) for 12-18 year olds.
RESULTSfrom the stratified analysis in the 2-6 year-olds, statistically significant differences were seen. When birth weight increased 0.5 kg per fold, the risk of overweight and obesity increased by 0.87 times among the dizygotic twins, more than that of the monozygotic twins (OR=1.86, 95%CI:1.24-2.81). The risk for male twins was 1.12 times higher than that of female twins (OR=1.65, 95%CI:1.11-2.44).
CONCLUSIONSBirth weight seemed associated with overweight and obesity for kids at early childhood or at age for schools. However, guidance on the implementation of public health interventions is still needed on these children.