Combined effects of both cardiovascular disease family history and smoking on the incidence of ischemic stroke.
- Author:
Qin LU
1
;
Jianhui ZHANG
2
;
Yongyue LIU
3
;
Hongmin LU
2
;
Yunfan TIAN
1
;
Batu BUREN
3
;
Yipeng ZHOU
1
;
Yonghong ZHANG
1
Author Information
- Publication Type:Journal Article
- MeSH: Alcohol Drinking; Asian Continental Ancestry Group; ethnology; genetics; Blood Glucose; Blood Pressure; Body Mass Index; Cardiovascular Diseases; ethnology; genetics; Cholesterol; Cholesterol, LDL; Genetic Predisposition to Disease; Humans; Incidence; Male; Mongolia; epidemiology; Population Surveillance; Proportional Hazards Models; Prospective Studies; Risk Factors; Smoking; adverse effects; epidemiology; Stroke; epidemiology; genetics
- From: Chinese Journal of Epidemiology 2016;37(4):475-479
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the cumulative effect regarding the family history of cardiovascular disease and smoking on ischemic stroke events in population with Mongolian ethnicity.
METHODSBased on data gathered from the baseline investigation, a 10-year prospective cohort follow-up project was conducted among 2 589 participants with Mongolian ethnicity. Ischemic stroke events were defined as the outcomes of the study. All the 2 589 participants were categorized into four subgroups: without family history of cardiovascular disease/nonsmokers, without family history of cardiovascular disease/smokers, with family history of cardiovascular disease/nonsmokers and with family history of cardiovascular disease/smokers, according to family history of cardiovascular disease and smoking status. Cumlative incidence rates of events among the four subgroups was described with Kaplan-Meier curves. Cox proportional hazards model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (95%CI) of ischemic stroke events among the four subgroups.
RESULTSData from the Kaplan-Meier curves showed that the cumulative incidence rates of ischemic stroke were 1.17% (15/1 278), 3.83% (37/967), 5.70% (9/158) and 8.33% (15/180) for the groups of no family history of cardiovascular disease/nonsmokers, no family history of cardiovascular disease/smokers, with family history of cardiovascular disease/nonsmokers and with family history of cardiovascular disease/smokers, respectively. By cox proportional hazards model, after adjusting for age, male, drinking status, systolic and diastolic blood pressure, body mass index, fasting glucose, total cholesterol, triglycerides, LDL cholesterol factors, the HRs (95% CI) of ischemic stroke were 2.26 (1.19-4.28) and 2.45 (1.13-5.33) in the no family history of cardiovascular disease/smokers group, with family history of cardiovascular disease/smokers group when compared to the no family history of cardiovascular disease/nonsmokers group, respectively. The risk of ischemic stroke appeared the highest in the group with family history of cardiovascular disease/smokers (all P<0.05).
CONCLUSIONSmoking may increase the risk of ischemic stroke events among the population with family history of cardiovascular disease.