An 11-year review of dermatomyositis in Asian patients.
- Author:
Wen Chun LIU
1
;
Madeline HO
;
Woon-Puay KOH
;
Audrey W H TAN
;
Patricia P L NG
;
Sze Hon CHUA
;
Suat Hoon TAN
;
Mark B Y TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma; Confidence Intervals; Dermatomyositis; complications; epidemiology; immunology; pathology; Female; Humans; Logistic Models; Male; Middle Aged; Muscle Weakness; Nasopharyngeal Neoplasms; epidemiology; immunology; pathology; Odds Ratio; Paraneoplastic Syndromes; complications; epidemiology; immunology; pathology; Retrospective Studies; Risk Factors; Singapore; epidemiology; Young Adult
- From:Annals of the Academy of Medicine, Singapore 2010;39(11):843-847
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONDermatomyositis (DM) is a multisystem inflammatory disease with a strong association with malignancy. We aimed to describe a series of Asian patients with DM and identify any significant clinical factors associated with malignancy.
MATERIALS AND METHODSThis was a retrospective review of a multi-racial cohort of 69 Asian patients diagnosed with DM over an 11-year period from 1996 to 2006.
RESULTSMalignancy was detected in 15 out of 68 patients (22%), the most common of which was nasopharyngeal carcinoma (7 cases). Compared to the non-malignancy group, the malignancy-associated group was older and had more male patients. There were no statistically significant clinical, serological or laboratory factors associated with a higher risk of malignancy.
CONCLUSIONThis study highlights the importance of ongoing malignancy screening especially for nasopharyngeal carcinoma in Asian patients with DM.
