Interface tissue engineering: next phase in musculoskeletal tissue repair.
- Author:
Sambit SAHOO
1
;
Thomas Kh TEH
;
Pengfei HE
;
Siew Lok TOH
;
James Ch GOH
Author Information
1. Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH 44195, USA. sambit.sahoo@gmail.com
- Publication Type:Journal Article
- MeSH:
Cell- and Tissue-Based Therapy;
Genetic Therapy;
Humans;
Intercellular Signaling Peptides and Proteins;
Musculoskeletal Diseases;
rehabilitation;
therapy;
Orthopedic Procedures;
instrumentation;
methods;
Osteogenesis;
Regenerative Medicine;
instrumentation;
methods;
Singapore;
Stem Cells;
Stress, Mechanical;
Tissue Engineering;
instrumentation;
methods;
Tissue Scaffolds;
Weight-Bearing
- From:Annals of the Academy of Medicine, Singapore
2011;40(5):245-251
- CountrySingapore
- Language:English
-
Abstract:
Increasing incidence of musculoskeletal injuries coupled with limitations in the current treatment options have necessitated tissue engineering and regenerative medicine- based approaches. Moving forward from engineering isolated musculoskeletal tissues, research strategies are now being increasingly focused on repairing and regenerating the interfaces between dissimilar musculoskeletal tissues with the aim to achieve seamless integration of engineered musculoskeletal tissues. This article reviews the state-of-the-art in the tissue engineering of musculoskeletal tissue interfaces with a focus on Singapore's contribution in this emerging field. Various biomimetic scaffold and cellbased strategies, the use of growth factors, gene therapy and mechanical loading, as well as animal models for functional validation of the tissue engineering strategies are discussed.
