Safety and immunogenicity of low-dose hepatitis B vaccine produced by National Institute of Hygiene and Epidemiology in newborns.
- Author:
Dat Tuan Do
- Publication Type:Journal Article
- Keywords:
hepatitis B
- MeSH:
Hepatitis B;
Infant, Newborn;
Hepatitis B Vaccines
- From:Journal of Preventive Medicine
2002;12(1):30-36
- CountryViet Nam
- Language:Vietnamese
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Abstract:
2 reduced doses of plasma-derived hepatitis B vaccine produced by the National Institute of Hygiene an Epidemiology (NIHE): 2.5g (VN2,5) and 5g (VN5) was compared with 2 pediatric standard doses (10g) of recombinant vaccine from 2 Korean companies. The vaccines were administrated intramuscularly in 700 neonates at months 0, 1, 2 with postvaccineation serology tested at month 8. The seroconversion rate of 2 reduced doses are comparable with 2 control groups. Geometric mean titer of low-risk newborns in group VN2,5 were similar to group VN5, but significantly lower than control groups.
