G6PD deficiency among children under 7 years old from Yunnan with unique ethnic minority origin.
- VernacularTitle:SNP芯片技术产前鉴别额外小标记染色体
- Author:
Li-qin YAO
1
;
Tuan-biao ZOU
;
Xing-tian WANG
;
Xing QUAN
;
Qian CHEN
;
Fa-bin YANG
;
Li-sha HU
;
Li-mei FAN
;
Min WANG
;
Xi-yun FENG
;
Jin-tao LIU
;
Zhong-ming ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; China; ethnology; Female; Glucosephosphate Dehydrogenase Deficiency; ethnology; genetics; Humans; Infant; Infant, Newborn; Logistic Models; Male
- From: Chinese Journal of Medical Genetics 2013;30(2):189-194
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the epidemiological status of glucose-6-phosphate dehydrogenase (G6PD) deficiency among children from Yunnan with unique ethnic origins.
METHODSDNA samples from 11759 children were tested with fluorescent spot test, G6PD/6PGD quantitative ratio assay and hemoglobin electrophoresis.
RESULTSThe detection rate of G6PD deficiency was 2.5%, for which boys were significantly greater than girls (3.5% vs. 1.4%, P<0.05). Significant differences were also detected among children from different ethnic groups and different regions. For ethnic Han Chinese, the detection rate was 0.7%, which was lower than the majority of ethnic minorities. By regression analysis, altitude of residence and family history both have significant influence on the calculated rate.
CONCLUSIONOccurrence of G6PD deficiency seems to be influenced by gender. It also varies substantially between different ethnic groups as well as regions, e.g., more common in south. It also showed a declining trend after years of diagnosis and intervention. This survey may provide a valuable basis for counseling of G6PD deficiency in Yunnan.
