Association between polymorphisms of PSMB8, PSMB9 and TAP2 genes with rheumatoid arthritis in ethnic Han Chinese from Yunnan.
- Author:
Liang YU
1
;
Qin LI
;
Jun LIN
;
Juan YU
;
Qian LI
;
Wei YI
;
Hao SUN
;
Jia-you CHU
;
Zhao-qing YANG
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette Transporters; genetics; ATP-Binding Cassette, Sub-Family B, Member 3; Arthritis, Rheumatoid; genetics; Case-Control Studies; China; ethnology; Cysteine Endopeptidases; genetics; Female; Gene Frequency; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex; genetics
- From: Chinese Journal of Medical Genetics 2013;30(2):222-226
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between single nucleotide polymorphisms (SNPs) of PSMB8, PSMB9 and TAP2 genes and rheumatoid arthritis (RA) in ethnic Han Chinese from Yunnan.
METHODSA case-control study was carried out using 177 RA patients and 288 healthy controls. Genotypes of rs2071543, rs55745125 and rs138635403 loci of PSMB8 gene, and rs17587 locus of PSMB9 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). And a polymerase chain reaction amplification refractory mutation system (ARMS-PCR) was used for typing rs2228396 locus of TAP2 gene. Genotypic and allelic frequencies were calculated. An Epi Info 7 software was used to calculate the Odds Ratio (OR) of above SNPs between the two groups.
RESULTSAllelic and genotypic frequencies of rs138635403 and rs17587 loci have differed significantly between the two groups (P<0.05). The frequency of GG genotype for rs17587 locus was also higher in the RA group (0.672) compared with control group (0.524) (OR=1.862, 95%CI: 1.261-2.749).
CONCLUSIONGenetic polymorphisms of rs17587 appeared to be associated with RA in ethnic Han Chinese from Yunnan.
