Polymorphisms of (CAG)n and(GGN)n repeats of androgen receptor gene among ethnic Hui and Han Chinese from Ningxia.
- VernacularTitle:宁夏回、汉族群体雄激素受体基因(CAG)n、(GGN)n重复多态性研究
- Author:
Chuan ZHANG
1
;
Mengjing GUO
;
Liguo PEI
;
Hao ZHU
;
Fei JIA
;
Lei QU
;
Jie DANG
;
Hong LU
;
Zhenghao HUO
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; genetics; Base Sequence; China; ethnology; Female; Genotype; Humans; Male; Molecular Sequence Data; Polymorphism, Genetic; Population Groups; genetics; Receptors, Androgen; genetics; Trinucleotide Repeat Expansion; Trinucleotide Repeats
- From: Chinese Journal of Medical Genetics 2013;30(3):365-369
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the distribution of (CAG)n and (GGN)n repeats polymorphisms of androgen receptor (AR) gene between Hui and Han ethnic Chinese from Ningxia.
METHODSGenotypes of above repeats were determined with DNA sequencing method.
RESULTSThe distribution of (GGN)n repeats was significantly different between the two ethnic groups (P< 0.01), though no such difference was detected with (CAG)n repeats (P> 0.05). Particularly, Han Chinese women carrying 23 GGN repeats were significantly fewer (48.4%) than Hui women (64.7%, P=0.01).
CONCLUSIONThe distribution of GGN repeat is significantly differently among Hui and Han Chinese ethnics from Ningxia.
