Family-based association study of a variable number of tandem repeat polymorphism of DAT1 gene with Tourette syndrome in a Chinese Han population.
- Author:
Lanlan ZHENG
1
;
Zhen-liang HAN
;
Xin-hua ZHANG
;
Xue-qin WANG
;
Wei-hua JIANG
;
Ming-ji YI
;
Shi-guo LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; ethnology; genetics; Child; Child, Preschool; Dopamine Plasma Membrane Transport Proteins; genetics; Female; Humans; Male; Minisatellite Repeats; Pedigree; Polymorphism, Genetic; Tourette Syndrome; ethnology; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2013;30(5):594-597
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of a 40 bp variable number of tandem repeat (VNTR) polymorphism within 3 untranslated region of dopamine transporter gene (DAT1) with Tourette syndrome (TS) in a Chinese Han population.
METHODSA total of 160 TS patients and their parents were recruited. The VNTR polymorphism was detected with polymerase chain reaction-VNTR analysis, and its association with TS and its subtypes were assessed through a family-based association study comprising transmission disequilibrium test (TDT) and haplotype relative risk (HRR) analysis.
RESULTSThe repeat numbers at the DAT1 40 bp locus were 11, 10, 9, 7.5 and 7 among the patients and their parents, with the most common type being a 10-repeat allele. No significant association was detected between the polymorphism and TS (TDT: X ² = 0.472, df = 1, P = 0.583; HRR: X ² = 0.313, P = 0.576, OR = 0.855, 95%CI: 0.493-1.481).
CONCLUSIONOur data suggested that the VNTR polymorphism of DAT1 gene is not associated with susceptibility to TS in Chinese Han population. However, our results are to be validated in larger sets of patients collected from other populations.
