Significance of plasmic homocysteine, folate and Vitamin B(12) in ulcerative colitis.
- Author:
Mo-Li CHEN
1
;
Qiao MEI
;
Jian-Ming XU
;
Nai-Zhong HU
;
Chun-Xia LU
;
Hai-Ming FANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Case-Control Studies; Colitis, Ulcerative; blood; Female; Folic Acid; blood; Homocysteine; blood; Humans; Male; Middle Aged; Vitamin B 12; blood; Young Adult
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(3):185-187
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical significance of plasmic homocysteine (Hcy), folate (FA) and Vitamin B(12) (VitB(12)) in patients with ulcerative colitis (UC).
METHODSPlasmic Hcy in 112 cases of UC patients and 110 controls were detected by HPLC-FD method. Plasmic FA, VitB(12) in 76 cases of UC patients and 12 controls were detected by enzyme-linked immunosorbent assay (ELISA) method.
RESULTSThe level of plasmic Hcy in UC patients was(11.27±7.26) μmol/L, significantly higher than that in controls[(8.19±4.81) μmol/L, P<0.05], and was not significantly correlated with disease index, extent and duration of UC(P>0.05). The level of FA and VitB(12) in UC patients were (7.64±1.95) nmol/L and (108.64±32.22) pmol/L respectively, lower than those in controls[(9.14±1.23) nmol/L and (112.64±33.33) pmol/L, P<0.05]. The level of plasmic Hcy was negatively correlated with the level of FA and VitB(12) in UC patients(P<0.05). The level of plasmic FA decreased to some extent with UC disease duration.
CONCLUSIONPlasmic Hcy is elevated in UC patients, which may be related to the decrease of FA and VitB(12).
