Effect of Campath-1H induction on immunosuppression in small intestine transplantation.
- Author:
Jian ZHOU
1
;
Wei-Qiang JU
;
Xiao-Shun HE
;
Dong-Ping WANG
;
Xiao-Feng ZHU
;
Lin-Wei WU
;
Qiang TAI
;
Yi MA
;
An-Bin HU
;
Guo-Dong WANG
;
Jie-Fu HUANG
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Alemtuzumab; Antibodies, Monoclonal, Humanized; therapeutic use; Graft Rejection; prevention & control; Humans; Immunosuppression; Immunosuppressive Agents; therapeutic use; Intestine, Small; transplantation; Male; Retrospective Studies
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(3):199-201
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Campath-1H induction on immunosuppression in small intestine transplantation.
METHODSClinical data of a patient who underwent small intestine transplantation were retrospectively summarized.
RESULTSIntraoperative Campath-1H induction by intravenous injection was administered. Triple immunosuppression(FK506, MMF and methylprednisolone) was used postoperatively. The lymphocyte and leukocyte decreased significantly following Campath-1H induction, and returned to normal after adjusting the dose of immunosuppressant and use of colony stimulating factor. There were no acute rejection, graft versus host disease, or severe infection during the immediate postoperative period. The patient recovered and discharged.
CONCLUSIONIntraoperative Campath-1H induction and postoperative triple immunosuppression using FK506, MMF, and methylprednisolone may prevent rejection and graft versus host disease in the early stage after small intestine transplantation.
