Clinical significance of signal transduction and activators of transcription 3, E-cadherin and vimentin in colon cancer.
- Author:
Chao ZHANG
1
;
Jian-Hua XU
;
Tao LIU
;
Hao CUI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Cadherins; metabolism; Colonic Neoplasms; metabolism; pathology; Female; Humans; Male; Middle Aged; STAT3 Transcription Factor; metabolism; Vimentin; metabolism
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(3):202-205
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the clinical significance of STAT3, E-cadherin and vimentin in colon cancer.
METHODSSamples of colon cancer tissue and adjacent normal tissue were procured from 70 patients with colon cancer. The expressions of STAT3, E-cadherin and vimentin were detected by immunohistochemistry. Associations of clinicopathological characteristics and these three factors were evaluated.
RESULTSSTAT3, E-cadherin, vimentin were positive in 74.3%,32.9%, and 78.6% in the colon cancer tissues, respectively, and were 15.7%, 82.9%, and 12.9% in normal colon mucosa tissues, respectively. They were correlated with tumor differentiation, depth of invasion, lymph node metastasis, and TNM staging(P<0.05). There was a positive correlation between STAT3 and vimentin expression(P<0.01). However, STAT3 was negatively correlated with E-cadherin(P<0.01).
CONCLUSIONSSTAT3, E-cadherin and vimentin are closely associated with colon cancer. The expressions of STAT3, E-cadherin and vimentin may serve as prognostic indicators for patients with colon cancer.
