Oral glucose tolerance test and insulin response in Beagle dogs after subtotal distal gastrectomy.
- Author:
Zai-Yuan YE
1
;
Wei ZHANG
;
Qin ZHANG
;
Qiao-Qiong DAI
;
Qin-Shu SHAO
;
Yuan-Shui SUN
;
Yuan-Yu WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; metabolism; Digestive System Surgical Procedures; methods; Dogs; Female; Gastrectomy; methods; Glucose Tolerance Test; Insulin; blood; Male
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(3):210-212
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the impact of reconstruction techniques after subtotal gastrectomy on postoperative glucose and insulin levels after oral glucose tolerance test (OGTT).
METHODSDistal gastrectomy was performed in 38 Beagle dogs. Reconstruction techniques used included integral continual jejunal interposition (n=9), Billroth I( (n=6), Billroth II( (n=7), and isolated jejunal interposition (n=8). Eight controls were used. OGTT was conducted to examine the changes in glucose and insulin levels.
RESULTSCompared to controls, glucose significantly increased in all the 4 operative groups and peaked at 60 min. Billroth II( was associated with the most significant increase. Insulin level significantly increased in all the experimental groups in response to food stimulus and peaked at 60 min. However, the increase of insulin in Billroth II( group was not as prominent as in other groups.
CONCLUSIONSFluctuation of blood glucose after gastrectomy may be mitigated and insulin elevated if duodenal passage is preserved. Continual jejunal interposition should be given priority when Billroth I( reconstruction is not feasible.
