Analysis of risk factors associated with lymph node metastasis and prognosis of T1-2 colorectal cancer.
- Author:
Rui CHAI
1
;
Chuan-gang FU
;
Hao WANG
;
Lian-jie LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Colorectal Neoplasms; diagnosis; pathology; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Logistic Models; Lymph Nodes; pathology; Lymphatic Metastasis; diagnosis; pathology; Male; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Factors
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(4):245-248
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate factors associated with lymph node metastasis and prognosis in patients with T1-2 colorectal cancer.
METHODSPatients with pT1-2 colorectal cancer between January 1999 to January 2005 were included. Chi-square test and multivariable logistic analysis were performed to evaluate risk factors associated with lymph node metastasis. Survival outcomes were analyzed using Kaplan-Meier and Cox regression model.
RESULTSTumor location and depth of invasion were independent risk factors for lymph node metastasis(P<0.01 and P<0.05). Gender, age, tumor gross pattern, tumor differentiation, carcinoembryonic antigen level, and tumor diameter were not associated with lymph node metastasis. Lymph node metastasis and distant metastasis on postoperative follow-up were independent risk factors for survival(P<0.05 and P<0.01).
CONCLUSIONFactors associated with lymph node metastasis in pT1-2 colorectal cancer do not affect the survival. However, lymph node metastasis and distant metastasis are predictive for survival.
