Associated risk factors of peritoneal metastasis in colorectal cancer.
- Author:
Feng LIU
1
;
Jiang YU
;
Yao-ze LIANG
;
Yan-feng HU
;
Ya-nan WANG
;
Guo-xin LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Colorectal Neoplasms; diagnosis; pathology; Female; Humans; Logistic Models; Male; Middle Aged; Neoplasm Metastasis; Peritoneum; pathology; Prognosis; Retrospective Studies; Risk Factors; Young Adult
- From: Chinese Journal of Gastrointestinal Surgery 2011;14(4):254-256
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate risk factors associated with peritoneal metastasis in colorectal cancer.
METHODSClinicopathological data of 873 patients with colorectal cancer treated at the Nanfang Hospital of Southern Medical University from January 2003 to December 2008 were retrospectively analyzed. The associations between peritoneal metastasis and clinicopathological factors were evaluated by univariate analysis including independent-samples t test and χ(2) test, and multivariable logistic regression analysis.
RESULTSUnivariate analysis showed that age(P=0.032), tumor size(P=0.001), tumor differentiation(P=0.008), depth of bowel wall invasion(P=0.000), lymph node metastasis(P=0.000), serum carcinoembryonic antigen (CEA) level(P=0.003), and serum carbohydrate antigen 19-9(CA19-9) level(P=0.009) were associated with peritoneal metastasis. On multivariable logistic regression analysis, depth of bowel wall invasion, lymph node metastasis, serum CEA level and CA19-9 level remained as significant risk factors(all P<0.05).
CONCLUSIONDepth of bowel wall invasion, lymph node metastasis, serum CEA level, and CA19-9 level are risk factors for peritoneal metastasis in colorectal cancer.
