Expression and clinical impact of vascular endothelial growth factor and matrix metalloproteinase-2 in hepatocellular carcinoma.
- Author:
Rong-ping GUO
1
;
Chong ZHONG
;
Ming SHI
;
Chang-qing ZHANG
;
Wei WEI
;
Ya-qi ZHANG
;
Jin-qing LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Hepatocellular; metabolism; mortality; surgery; Disease-Free Survival; Female; Follow-Up Studies; Hepatectomy; Humans; Liver Cirrhosis; complications; Liver Neoplasms; metabolism; mortality; surgery; Male; Matrix Metalloproteinase 2; metabolism; Middle Aged; Neoplasm Recurrence, Local; Neoplastic Cells, Circulating; metabolism; Prognosis; Proportional Hazards Models; Survival Rate; Vascular Endothelial Growth Factor A; metabolism
- From: Chinese Journal of Oncology 2006;28(4):285-288
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and clinical impact of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in hepatocellular carcinoma (HCC).
METHODSNinety specimens obtained from HCC patients were examined immunohistochemically using anti-VEGF and anti-MMP-2 monoclonal antibodies.
RESULTSThe positive rates of VEGF and MMP-2 expression in HCC tissues were 76.7% and 60%, respectively. The expression of MMP-2 in HCC tissues was positively correlated with the expression of VEGF (r(s) = 0.32) and both were positively correlated with recurrence (or metastasis) after hepatectomy (r(s) = 0.31, r(s) = 0.32). 2-year tumor-free survival rates of VEGF- group, VEGF+ group and VEGF++ group were 71.4%, 43.5%, 30.4%, respectively, (P < 0.01), while MMP-2- group 66.7% and MMP-2+ group 32.8% (P < 0.01). Multivariate analysis revealed that the expression of VEGF and MMP-2 in HCC tissues, tumor microthrombus and pre-operative dissemination to lymph nodes were independent recurrence (or metastasis) risk factors.
CONCLUSIONThe expression of VEGF and MMP-2 in HCC tissues, and clinicopathological features (tumor microthrombus and pre-operative dissemination to lymph nodes), could be regarded as valuable indicators for prediction of recurrence (or metastasis) risk in HCC patients.
