Molecular cytogenetic characteristics of chronic lymphocytic leukemia.
- Author:
Wei XU
1
;
Jian-yong LI
;
Jin-lan PAN
;
Hai-rong QIU
;
Yun-feng SHEN
;
Bing XIAO
;
Li-juan CHEN
;
Ya-fang WU
;
Rui-lan SHENG
;
Yong-quan XUE
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 17; Female; Humans; In Situ Hybridization, Fluorescence; Leukemia, Lymphocytic, Chronic, B-Cell; genetics; Male; Middle Aged; Trisomy
- From: Chinese Journal of Oncology 2006;28(5):349-352
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the molecular cytogenetic characteristics in patients with chronic lymphocytic leukemia (CLL).
METHODSInterphase fluorescence in situ hybridization (FISH) was used to detect trisomy 12, deletion of 13q14 and 17p13 in 60 patients with CLL.
RESULTSOut of the 60 patients, 41 (68.3%) had at least one kind of molecular cytogenetic aberrations. Two (3.3%) had two kinds of abnormalities. Trisomy 12 was found in 12 (20.0%) cases, 13q14 deletion in 24 (40.0%) cases and 17p13 deletion in 5 (11.7%) cases. The number of trisomy 12 cells ranged from 4.0% to 34.0%, 13q14 deletion ranged from 22.0% to 93.0% and 17p13 deletion ranged from 6.0% to 68.0%. There was no significant difference among each Binet stages.
CONCLUSIONFISH is a more rapid, accurate and sensitive technique in analysis of chromosome aberrations in CLL. FISH may provide accurate information of molecular cytogenetics for CLL.
