Prognostic predictors of nasal NK/T cell lymphoma detected by immunohistochemical staining.
- Author:
Bi-Yun WANG
1
;
Xiao-Nan HONG
;
Ji-Liang YIN
;
Hong-Fen LU
;
Xiao-Qiu LI
;
Xue-Jun MA
;
Ye GUO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Biomarkers, Tumor; analysis; Cyclophosphamide; therapeutic use; Doxorubicin; therapeutic use; Female; Follow-Up Studies; Humans; Hyaluronan Receptors; analysis; Immunohistochemistry; statistics & numerical data; Inhibitor of Apoptosis Proteins; Ki-67 Antigen; analysis; Killer Cells, Natural; drug effects; metabolism; pathology; Lymphoma, T-Cell; drug therapy; metabolism; pathology; Male; Microtubule-Associated Proteins; analysis; Middle Aged; Neoplasm Proteins; analysis; Neoplasm Staging; Nose Neoplasms; drug therapy; metabolism; pathology; Prednisone; therapeutic use; Prognosis; Proportional Hazards Models; Vincristine; therapeutic use; fas Receptor; analysis
- From: Chinese Journal of Oncology 2006;28(7):523-525
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the prognostic predictors of nasal NK/T cell lymphoma.
METHODSThe clinicopathologic feature data of 61 patients with nasal NK/T cell lymphoma proven by pathological examination from Jan. 1997 to Jan. 2005 were collected. Expression of survivin, CD44, nm23, p53, Ki-67, MDR-1 and CD95 was detected by immunohistochemical staining in 30 patients with available histologic specimens. The correlation between these factors and prognosis were analyzed.
RESULTSIn univariate analysis, performance status, LDH level, clinical stage, initial treatment response, CD56, Ki-67 and CD95 were found to be the prognostic factors associated with time to progression (TTP) in nasal NK/T cell lymphoma, while the performance status, B symptoms, LDH level, initial treatment response, Ki-67 and CD95 were demonstrated as prognostic factors related to overall survival. In multivariate analysis, clinical stage, initial treatment response and performance status were independent prognostic factors for TTP, while the latter two factors were independent prognostic factors of overall survival.
CONCLUSIONClinical stage and initial treatment response, and performance status are found to be independent prognostic factors for TTP, whereas the latter two factors are demonstrated as independent prognostic factors of the overall survival. Overexpression of Ki-67 may be an unfavorable prognostic factor, but overexpression of CD95 may be a favorable one.
