Changes to CD4(+)CD25(high+)CD127(low) regulatory T cells in peripheral blood from children with bronchiolitis, and its clinical significance.
- Author:
Xiu-Fang WANG
1
;
Zhi-Lan GUO
;
Rui-Rui LEI
;
Ying HAN
Author Information
- Publication Type:Journal Article
- MeSH: Bronchiolitis; immunology; Child, Preschool; Female; Flow Cytometry; Humans; Infant; Interleukin-2 Receptor alpha Subunit; blood; Interleukin-7 Receptor alpha Subunit; blood; Male; T-Lymphocytes, Regulatory; immunology
- From: Chinese Journal of Contemporary Pediatrics 2013;15(1):46-49
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study changes to CD4(+)CD25(high+)CD127(low) regulatory T cells (Treg) in peripheral blood from children with bronchiolitis, and to explore its clinical significance.
METHODSThirty-one children with bronchiolitis and aged under two years were randomly enrolled as the bronchiolitis group, and 25 under two-year-olds with bronchopneumonia were randomly enrolled as the bronchopneumonia group. A further twenty-five children with non-infectious diseases such as hernia and renal calculus served as the control group. The level of CD4(+)CD25(high+)CD127(low) Treg in peripheral blood was measured by multi-color detection and multi-parameter flow cytometry.
RESULTSThe proportion of CD4(+)CD25(high+)CD127(low) Treg in peripheral blood in the bronchiolitis group (8.0%±2.1%) was significantly lower than in the bronchopneumonia (9.6%±2.6%; P<0.05) and control groups (11.3%±2.9%; P<0.05).
CONCLUSIONSCD4(+)CD25(high+)CD127(low) Treg level in peripheral blood may be an index of immunological function in infants. A decreased level of CD4(+)CD25(high+)CD127(low) Treg in peripheral blood suggests that Treg cells may be involved in the pathogenesis and development of bronchiolitis.
