CT manifestations of liver involvement in children with Langerhans cell histiocytosis.
- Author:
Hui LIU
1
;
Xue-Ying LONG
;
Wen-Zheng LI
;
Xiao-Yi WANG
;
Jue CAO
;
Zhi-Jun LIU
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Female; Hepatomegaly; diagnostic imaging; Histiocytosis, Langerhans-Cell; complications; diagnostic imaging; Humans; Infant; Liver; diagnostic imaging; pathology; Male; Retrospective Studies; Tomography, X-Ray Computed; methods
- From: Chinese Journal of Contemporary Pediatrics 2013;15(2):121-124
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the computed tomography (CT) manifestations of liver involvement in children with Langerhans cell histiocytosis (LCH).
METHODSRetrospective analysis was performed on 9 LCH children with liver involvement confirmed by clinical, laboratory and pathological examinations to investigate the CT manifestations of this condition. These children, including 6 males and 3 females, had undergone both plain CT scan and dual-phase (the arterial and portal venous phases) contrast-enhanced CT scan.
RESULTSThe main CT manifestations included hepatomegaly (8 cases); periportal dendritic hypodense lesions or "periportal halo sign" (7 cases) which were mildly or moderately enhanced in the arterial phase; intrahepatic bile duct dilatation (5 cases); lymphadenopathy in the hepatic hilar or retroperitoneal region (4 cases); and diffuse small hypodense nodules (3 cases), which showed annular enhancement on the contrast-enhanced CT scan.
CONCLUSIONSCT findings may be helpful in the early diagnosis and treatment of LCH in children.
