The Relationship between ABO Blood Group Phenotypes and Seroprevalence of Infectious Disease in Korea.
- Author:
Hae Bong JANG
1
;
Sang Gyung KIM
;
A Jin LEE
;
Hun Suk SUH
;
Chang Ho JEON
;
Ho Sung AHN
Author Information
1. Department of Laboratory Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. sgkim@cu.ac.kr
- Publication Type:Original Article
- Keywords:
ABO blood group;
Seroprevalence;
Hepatitis B surface antigen;
Clostridium difficile
- MeSH:
Blood Group Antigens;
Clostridium difficile;
Communicable Diseases*;
Continental Population Groups;
Hepatitis B Surface Antigens;
Herpesvirus 4, Human;
HIV;
Humans;
Immunoglobulin M;
Korea;
Logistic Models;
Medical Records;
Odds Ratio;
Phenotype*;
Retrospective Studies;
Seroepidemiologic Studies*
- From:Korean Journal of Blood Transfusion
2014;25(2):113-122
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The distribution of ABO and Rhesus D (RhD) blood group antigens differs according to race and region. Previous studies have reported that blood group type was associated with not only transfusion-related diseases but also various diseases, such as malignancy and infectious disease. However, true relationship of blood groups and many diseases remained controversial. The aim of this study was to determine whether ABO and RhD blood groups are correlated with several infectious diseases. METHODS: From January 2003 to December 2012, we retrospectively reviewed results for HBsAg, HCV Ab, HIV Ab, VDRL, HAV IgM, CMV IgM, EBV VCA IgM, and Clostridium difficile toxin A and B (CD toxin). We also reviewed ABO and RhD results of these patients. Data were analyzed using chi-square test and binary logistic regression test. Odds ratio and 95% confidence intervals were determined. RESULTS: A total of 109,898 medical records of ABO and HBsAg results were reviewed. Blood group type-A was more prone to have positive results with HBsAg, while blood group type-O was less affected (odds ratio 1.086, P=0.003, odds ratio 0.935, P=0.029, respectively). With 3,171 records of CD toxin, blood group type-O was more affected (odds ratio 1.247, P=0.027). The relationship of the other serologic results and blood groups was not statistically significant. CONCLUSION: Seroprevalence of HBsAg and CD toxin showed an association with blood group type. Blood group type-A had higher HBsAg seroprevalence than the other group. Blood group type-O was more prone to have CD toxin.
