Membranous Nephropathy Concurrent with Interstitial Nephritis after Allogenic Hematopoietic Stem Cell Transplantation in a Patient with Acute Lymphoblastic Leukemia.
- Author:
Hyun Woo LEE
1
;
Soo Hoon KANG
;
Ga Eun PARK
;
Kyung Ho LEE
;
Yun Soo HONG
;
Ghee Young KWON
;
Chul Won JUNG
;
Jung Eun LEE
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jungeun34.lee@samsung.com
- Publication Type:Case Report
- Keywords:
Membranous nephropathy;
Allogenic hematopoietic stem cell transplantation;
Graft-versus-host disease;
Interstitial nephritis
- MeSH:
Adult;
Biopsy;
Cyclosporine;
Female;
Glomerulonephritis, Membranous*;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation*;
Humans;
Kidney;
Methotrexate;
Nephritis, Interstitial*;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Proteinuria
- From:Korean Journal of Blood Transfusion
2014;25(2):152-159
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Kidney is rarely an involved organ of graft-versus-host disease (GVHD). Here, we report on a case of membranous nephropathy and interstitial nephritis after allogenic hematopoietic stem cell transplantation (HSCT) in a 44-year-old female patient with acute lymphoblastic leukemia. The patient received GVHD prophylaxis with low dose steroid, cyclosporin, and short course methotrexate. Cyclosporine was tapered out 17 months after allogeneic HSCT. Thereafter, the patient developed kidney impairment and nephrotic range proteinuria. Kidney biopsy revealed membranous nephropathy concurrent with interstitial nephritis.
