The lipid-regulating effects of atorvastatin on type 2 elder diabetes patients with hyperlipidemia.
- Author:
Ling TU
1
;
Xiaoqing LIU
;
Renli LI
;
Kui HUANG
;
Hanhua YAO
;
Qiao FAN
Author Information
1. Department of Integration, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Anticholesteremic Agents;
therapeutic use;
Atorvastatin Calcium;
Cholesterol, HDL;
blood;
Cholesterol, LDL;
blood;
Diabetes Mellitus, Type 2;
complications;
drug therapy;
Female;
Heptanoic Acids;
therapeutic use;
Humans;
Hyperlipidemias;
complications;
drug therapy;
Male;
Middle Aged;
Pyrroles;
therapeutic use;
Triglycerides;
blood
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(2):138-139
- CountryChina
- Language:English
-
Abstract:
To investigate the effect of atorvastatin on lipid metabolism in type 2 elder diabetes patients with hyperlipidemia, 26 patients with type 2 elder diabetes complicated with hyperlipidemia were treated with atorvastatin (10 mg/d) for 8 weeks. The serum triglyceride (TG), high density protein cholesterol (HDL-C) and low density protein cholesterol (LDL-C) were measured before and after the treatment. Meanwhile, the non-denaturing polyacrylamide gradient gel electrophoresis was used for detection of small-sized LDL(SLDL). Our results showed that TG dropped from 4.88 +/- 0.72 mmol/L to 2.65 +/- 0.32 mmol/L; HDL-C was increased from 0.85 +/- 0.31 mmol/L to 1.28 +/- 0.29 mmol/L; LDL-C was declined from 3.71 +/- 2.98 mmol/L to 2.10 +/- 1.22 mmol/L, sLDL-A was increased from (42.49 +/- 8.1)% to (53.27 +/- 7.5)%; LDL-B was decreased from (57.91 +/- 8.1)% to (46.73 +/- 7.5% ) (P<0.05). The level of blood glucose was not changed at the end of 8th week. It is concluded that atorvastatin has satisfactory lipid-regulating effects on type 2 elder diabetes patients with hyperlipidemia.
