Nitric oxide formation contributes to beta-adrenergic dilation of epicardial coronary arteries in response to intravenous administration of dobutamine in dogs.
- Author:
Haoyi YANG
1
;
Youbin DENG
;
Xiaojun BI
;
Qing CHANG
;
Jiao BAI
;
Min PAN
;
Huijuan XIANG
;
Hongyun LIU
;
Xiulan LI
;
Yani LIU
;
Chunlei LI
Author Information
1. Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Journal Article
- MeSH:
Adrenergic beta-Agonists;
pharmacology;
Animals;
Coronary Vessels;
physiology;
Dobutamine;
pharmacology;
Dogs;
Echocardiography;
Female;
Male;
Nitric Oxide;
physiology;
Receptors, Adrenergic, beta;
physiology;
Vasodilation;
physiology;
omega-N-Methylarginine;
pharmacology
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(2):189-191
- CountryChina
- Language:English
-
Abstract:
To examine the role of nitric oxide in the beta-adrenergic vasodilation of epicardial coronary arteries in dogs, 12 dogs were instrumented for measurement of left anterior descending coronary artery diameter by transthoracic echocardiography before and after dobutamine (5 microg/kg/min IV) with and without intracoronary infusion of NG-monomethyl-L-arginine (L-NMMA) (1 mg/kg). In all 12 dogs, the diameter of left anterior descending coronary artery increased significantly from 2.35 +/- 0.25 mm to 2.59 +/- 0.24 mm (P<0.001) after dobutamine administration. In 6 of the 12 dogs, the percent change in left anterior descending coronary artery diameter induced by dobutamine decreased significantly from 12.5% +/- 8.6% to -1.5% +/- 5.4% (P<0.05) after the administration of intracoronary L-NMMA (1 mg/kg for 5 min) to block nitric oxide synthesis from L-arginine. The study demonstrated that nitric oxide formation contributes to the beta-adrenergic dilatory response of epicardial coronary arteries to dobutamine in dogs.
