Inhibitory mechanism of inteferon-gamma on human fibroblasts from Tenon's capsule.
- Author:
Bo HAN
1
;
Yizhen HU
;
Xinchun XIONG
Author Information
1. Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 43002, China.
- Publication Type:Journal Article
- MeSH:
Conjunctiva;
metabolism;
pathology;
Connective Tissue;
drug effects;
Fibroblasts;
metabolism;
pathology;
Filtering Surgery;
Glaucoma;
pathology;
surgery;
Humans;
Interferon-gamma;
biosynthesis;
genetics;
Receptors, Transforming Growth Factor beta;
analysis
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2004;24(3):292-299
- CountryChina
- Language:English
-
Abstract:
The inhibitory mechanism of interferon-gamma (IFN-gamma) on the fibroblasts from Tenon's capsule was studied. By using immunohistochemical SP method and pathological image system, the inhibitory effects of IFN-gamma on the expression of transforming growth factor beta receptor I in the in vitro cultured fibroblasts from Tenon's capsule were quantitatively analyzed. The results showed that IFN-gamma could reduce the expression of transforming growth factor beta receptor I in the fibroblasts with the following dose-effect relationship: Y = 1937.5-134.2 Igx (r=-0.971, P<0.01). It was concluded that IFN-gamma could inhibit the expression of transforming growth factor beta receptor I in the fibroblasts from Tenon's capsule. The modulation of the transforming growth factor beta receptor I expression by IFN-gamma may be beneficial to the alleviation of the hyperplasia of scar after trabeculectomy.
